OverviewMedical UsesOculoplastic UsesHow it is doneExamplesRisksFAQ

Overview Botulinum toxin (Botox ®)

Botulinum Toxin is a reversible chemical treatment used for facial lines and wrinkles. It is part of aesthetic surgery or treatment.

It is sometimes called Botox but that is in fact the name of the botulinum made by one particular company. The two main companies are Allergan and Dyspor

Botulinum toxin has established medical uses, for instance eyelid conditions such as entropion (lower eyelid turning in), to lower the upper eyelid to protect the eye if exposed in severe facial paresis, for facial spasm (blepharospasm), neck spasm (torticollis) and some double vision.

Mode of action

Botulinum toxin A (BTX A) is a very powerful toxin which when injected in minute amounts into a muscle, will cause a temporary paralysis of that muscle. It works on the motor end plates of skeletal muscle. It also has an action on sympathetic smooth muscle and glands such as sweat glands (used to stop underarm sweating).

It blocks the release of a neurotransmitter acetylcholine necessary for initiating muscle contraction Its effect starts from between 3 to 7 days after injection and lasts between 2 and 6 months (average 4 months). The peak action is at 7 to 10 days after injection with complete paralysis of the muscle area treated, which then it gradually wears off. Injections can be repeated.